I have a long-standing research interest in developmental neurobiology and its implications for neurological diseases. In particular, I am fascinated by the precise assembly of complex nervous system components that are able to sense the environment and affect behavior. To pursue this question, I did my PhD in neuroscience in Dr. Yuh-Nung Jan's lab at University of California, San Francisco, where I discovered multiple genes that regulate dendrite development in Drosophila sensory neurons. As a postdoctoral fellow in Dr. David Ginty's lab at Harvard Medical School, I am now studying how touch sensory neurons develop in mammals, with the goal of finding new molecules that regulate the assembly of somatosensory system.

 

 

A single low-threshold mechanosensory neuron (Aδ-LTMR) in the skin

 

Publications

Meltzer, S., Santiago, C., Sharma, N., and Ginty D.D (2021). The Cellular and Molecular Basis of Somatosensory Neuron Development. Neuron. 109, 3736–3757.

Kuehn, E.D.*, Meltzer, S.*, Abraira V.E., Ho C., and Ginty D.D. (2019). Tiling and Somatotopic Alignment of Mammalian Low-Threshold Mechanoreceptors. Proc. Natl. Acad. Sci. U.S.A. 116, 9168–9177. (*equal contributions).

 

Meltzer, S., Bagley, J.A., Perez, G.L., O’Brien, C.E., DeVault, L., Guo, Y., Jan, L.Y., and Jan, Y.N. (2017). Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons. Cell Reports 21, 859–866.

•          Highlighted in Trends in Neuroscience: Miller III, D.M. and Sundararajan, L. Neuronal Fat and Dendrite Morphogenesis: The Goldilocks Effect (2018).

Jin, P., Bulkley, D., Guo, Y., Zhang, W., Guo, Z., Huynh, W., Wu, S., Meltzer, S., Cheng, T., Jan, L.Y., Jan, Y.N., Cheng, Y. (2017). Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature 547, 118–122.

 

Meltzer, S.*, and Chen, C.* (2016). Balancing Dendrite Morphogenesis and Neuronal Migration during Cortical Development. J. Neurosci. 36, 10726–10728. (*equal contributions)

 

Guo, Y.*, Wang, Y.*, Zhang, W.*, Meltzer, S.*, Zanini, D.*, Yu, Y., Li, J., Cheng, T., Guo, Z., Wang, Q., Jacobs, J.S., Sharma, Y., Eberl, D.F., Göpfert, M.C., Jan, L.Y., Jan, Y.N., Wang, Z. (2016). Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion. Proc. Natl. Acad. Sci. U.S.A. 113, 7243–7248. (*equal contributions)

Ori-McKenney, K.M., McKenney, R.J., Huang, H.H., Li, T., Meltzer, S., Jan, L.Y., Vale, R.D., Wiita, A.P., and Jan, Y.N. (2016). Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron 90, 1–14.

Meltzer, S., Yadav, S., Lee, J., Soba, P., Younger, S.H., Jin, P., Zhang, W., Parrish, J., Jan, L.Y., and Jan, Y.N. (2016). Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons. Neuron 89, 741–755.

•          Editor’s Choice in Science Signaling: Ferrarelli L.K. Epidermal signals confine dendrites (2016).

Song, Y., Sretavan, D., Salegio, E.A., Berg, J., Huang, X., Cheng, T., Xiong, X., Meltzer, S., Han, C., Nguyen, T.-T., Bresnahan JC, Beattie, M.S., Jan, L.Y., Jan, Y.N. (2015). Regulation of axon regeneration by the RNA repair and splicing pathway. Nat. Neurosci. 18, 817–825.

Gorczyca, D.A., Younger, S., Meltzer, S., Kim, S.E., Cheng, L., Song, W., Lee, H.Y., Jan, L.Y., and Jan, Y.N. (2014). Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila. Cell Reports 9, 1446–1458.

Yan, Z., Zhang, W., He, Y., Gorczyca, D., Xiang, Y., Cheng, L.E., Meltzer, S., Jan, L.Y., and Jan, Y.N. (2013). Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493, 221–225.

Wu, C.-S., Zhu, J., Wager-Miller, J., Wang, S., O'Leary, D., Monory, K., Lutz, B., Mackie, K., and Lu, H.-C. (2010). Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Eur. J. Neurosci. 32, 693–706. (cover)

 

Education and Training

2017-Present 

HHMI Hanna Gray Fellow, Department of Neurobiology, Harvard Medical School & the Howard Hughes Medical Institute

 

2012-2017

University of California, San Francisco 

Ph.D. in Neuroscience.

2006-2010

Peking University, China

B.S., Life Sciences, Magna Cum Laude. 

B. Phil., Philosophy (secondary major)

Awards and Honors

 

Grants and Fellowships

Jan 2019 - Present     HHMI Hanna Gray Fellowship: Postdoctoral Training Phase: $90,000/year for four years. Faculty Phase: $270,000/year for four years.

Jul 2018 - Jan 2019    NIH NRSA Postdoctoral Fellowship

Sep 2016 - Sep 2017  Dissertation Fellowship, American Association of University Women

Sep 2013 - Sep 2016  National Science Foundation Graduate Research Fellowship

Sep 2012 - Sep 2013  NIH NRSA Institutional Research Training Grant (T32)

2008-2009                   Chun-Tsung Fellowship, Peking University

Honors and Awards

2021   Women in Science Travel Fund, WIST Fund

2020   NINDS Scholarship, Keystone Symposia on "Somatosensation: From Detection to Perception"

2019   Harvard Brain Science Initiative Young Scientist Travel Award

2016   Chinese Government Award for Outstanding Students Abroad

2016   Chancellor’s Diversity Award for the Advancement of Women, UCSF

2016   1st Place, UCSF Chalk Art Contest

2015   ASGD Conference Travel Award, UCSF

2014   Earle C. Anthony Travel Award, UCSF

2014   Graduate Student Research Award, UCSF
2013   
Poster Award, UCSF Neuroscience Retreat

2010   Graduated magna cum laude, Peking University

2008, 2009  National Scholarship, Chinese Ministry of Education (most competitive scholarship in China)

2009   Chun-Tsung Scholar, Peking University

2007, 2008, 2009    Triple-A student, Peking University

 

News

07-06-2021: After working with me for the past 2+ years, Katelyn Comeau left the lab to pursue her PhD in Molecules, Cells and Organisms at Harvard University. Congratulations Katelyn and I'm very proud of you!!

 

06-07-2021: Emmanuella Asante joined the lab as a research assistant and she will help with me with my postdoc work. Welcome, Emmanuella!

 

06-05-2020: I completed the Cold Spring Harbor Course on Ion Channels in Synaptic and Neural Circuit Physiology!

09-03-2019: Lai Wei, an undergraduate student from Peking University, finished his summer research with me. It was great working with him and many thanks to Yuanpei College for supporting him! 

06-03-2019: Katelyn Comeau came back to the lab as a research technician and will work with me on sensory neuron development!

 

03-20-2019: My daughter March Meltzer was born!

 

09-12-2018: I received the Hanna Gray Fellowship from HHMI!! This fellowship will support both of my postdoctoral training in the Ginty lab and the establishment of my future independent laboratory!

Media: HHMI Awards Hanna Gray Fellowships to 15 Early Career Scientists

 

08-03-2018: Katelyn Comeau, an undergraduate student from Mount St. Mary's University finished her outstanding summer lab research with me. You'll be missed!

Media: Biochemistry Student Conducted Research at Harvard University

 

07-01-2018: I received the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship!

 

02-08-2018: Annie Chen, a freshman student from Simmons College joined the Ginty lab to work with me on my projects!

 

10-01-2017: I started my postdoc in Dr. David Ginty's lab at Harvard Medical School!

 

08-16-2017: I successfully defended my PhD!

 
Contact

Department of Neurobiology
Howard Hughes Medical Institute
Harvard Medical School
210 Longwood Ave
Armenise 437
Boston, MA 02115